Oscillatory Deficits in the Sub-Chronic PCP Rat Model for Schizophrenia Are Reversed by mGlu5 Receptor-Positive Allosteric Modulators VU0409551 and VU0360172

The cognitive deficits of schizophrenia are linked to imbalanced excitatory and inhibitory signalling in the prefrontal cortex (PFC), disrupting gamma oscillations. We previously demonstrated that two mGlu5 receptor-positive allosteric modulators (PAMs), VU0409551 and VU0360172, restore cognitive de...

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Detalles Bibliográficos
Autores principales: Brown, Jessica, Grayson, Ben, Neill, Joanna C., Harte, Michael, Wall, Mark J., Ngomba, Richard T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10047164/
https://www.ncbi.nlm.nih.gov/pubmed/36980260
http://dx.doi.org/10.3390/cells12060919

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10047164/
https://www.ncbi.nlm.nih.gov/pubmed/36980260
http://dx.doi.org/10.3390/cells12060919

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