Terminal Complement Activation Is Induced by Factors Released from Endplate Tissue of Disc Degeneration Patients and Stimulates Expression of Catabolic Enzymes in Annulus Fibrosus Cells

Terminal complement complex (TCC) deposition was identified in human degenerated discs. To clarify the role of terminal complement activation in disc degeneration (DD), we investigated respective activating mechanisms and cellular effects in annulus fibrosus (AF) cells. Isolated cells from human AF,...

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Detalles Bibliográficos
Autores principales: Kuhn, Amelie, Riegger, Jana, Teixeira, Graciosa Q., Huber-Lang, Markus, Lambris, John D., Neidlinger-Wilke, Cornelia, Brenner, Rolf E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10047197/
https://www.ncbi.nlm.nih.gov/pubmed/36980228
http://dx.doi.org/10.3390/cells12060887

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10047197/
https://www.ncbi.nlm.nih.gov/pubmed/36980228
http://dx.doi.org/10.3390/cells12060887

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