SH2 Domain-Containing Phosphatase-SHP2 Attenuates Fibrotic Responses through Negative Regulation of Mitochondrial Metabolism in Lung Fibroblasts

Background: We have previously shown that SHP2 downregulation may predispose fibroblasts to differentiate into myofibroblasts and proposed a role for SHP2 downregulation in the pathogenesis of idiopathic pulmonary fibrosis (IPF). Recent data have shown that SHP2 localizes to the mitochondrial interc...

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Detalles Bibliográficos
Autores principales: Karampitsakos, Theodoros, Galaris, Apostolos, Barbayianni, Ilianna, DeIuliis, Giuseppe, Ahangari, Farida, Sampsonas, Fotis, Sotiropoulou, Vasilina, Aidinis, Vassilis, Bennett, Anton M., Herazo-Maya, Jose D., Xylourgidis, Nikolaos, Bakakos, Petros, Bouros, Demosthenes, Kaminski, Naftali, Tzouvelekis, Argyrios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10047203/
https://www.ncbi.nlm.nih.gov/pubmed/36980473
http://dx.doi.org/10.3390/diagnostics13061166

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10047203/
https://www.ncbi.nlm.nih.gov/pubmed/36980473
http://dx.doi.org/10.3390/diagnostics13061166

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