BAP1 Malignant Pleural Mesothelioma Mutations in Caenorhabditis elegans Reveal Synthetic Lethality between ubh-4/BAP1 and the Proteasome Subunit rpn-9/PSMD13

The deubiquitinase BAP1 (BRCA1-associated protein 1) is associated with BAP1 tumor predisposition syndrome (TPDS). BAP1 is a tumor suppressor gene whose alterations in cancer are commonly caused by gene mutations leading to protein loss of function. By CRISPR-Cas, we have generated mutations in ubh-...

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Detalles Bibliográficos
Autores principales: Martínez-Fernández, Carmen, Jha, Sweta, Aliagas, Elisabet, Holmberg, Carina I., Nadal, Ernest, Cerón, Julián
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10047281/
https://www.ncbi.nlm.nih.gov/pubmed/36980270
http://dx.doi.org/10.3390/cells12060929

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10047281/
https://www.ncbi.nlm.nih.gov/pubmed/36980270
http://dx.doi.org/10.3390/cells12060929

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