Quantitative Phosphoproteomics Reveals the Requirement of DYRK1-Mediated Phosphorylation of Ion Transport- and Cell Junction-Related Proteins for Notochord Lumenogenesis in Ascidian

The dual-specificity tyrosine phosphorylation-regulated kinase (DYRK1) phosphorylates diverse substrates involved in various cellular processes. Here, we found that blocking the kinase activity of DYRK1 inhibited notochord development and lumenogenesis in ascidian Ciona savignyi. By performing phosp...

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Detalles Bibliográficos
Autores principales: Wang, Zhuqing, Ouyang, Xiuke, Tan, Zicheng, Yang, Likun, Dong, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10047359/
https://www.ncbi.nlm.nih.gov/pubmed/36980262
http://dx.doi.org/10.3390/cells12060921

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10047359/
https://www.ncbi.nlm.nih.gov/pubmed/36980262
http://dx.doi.org/10.3390/cells12060921

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