Zoledronic Acid Blocks Overactive Kir6.1/SUR2-Dependent K(ATP) Channels in Skeletal Muscle and Osteoblasts in a Murine Model of Cantú Syndrome

Cantú syndrome (CS) is caused by the gain of function mutations in the ABCC9 and KCNJ8 genes encoding, respectively, for the sulfonylureas receptor type 2 (SUR2) and the inwardly rectifier potassium channel 6.1 (Kir6.1) of the ATP-sensitive potassium (KATP) channels. CS is a multi-organ condition wi...

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Detalles Bibliográficos
Autores principales: Scala, Rosa, Maqoud, Fatima, McClenaghan, Conor, Harter, Theresa M., Perrone, Maria Grazia, Scilimati, Antonio, Nichols, Colin G., Tricarico, Domenico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10047381/
https://www.ncbi.nlm.nih.gov/pubmed/36980269
http://dx.doi.org/10.3390/cells12060928

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10047381/
https://www.ncbi.nlm.nih.gov/pubmed/36980269
http://dx.doi.org/10.3390/cells12060928

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