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Domain Architecture of the Nonreceptor Tyrosine Kinase Ack1

The nonreceptor tyrosine kinase (NRTK) Ack1 comprises a distinct arrangement of non-catalytic modules. Its SH3 domain has a C-terminal to the kinase domain (SH1), in contrast to the typical SH3-SH2-SH1 layout in NRTKs. The Ack1 is the only protein that shares a region of high homology to the tumor s...

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Detalles Bibliográficos
Autores principales: Kan, Yagmur, Paung, YiTing, Seeliger, Markus A., Miller, W. Todd
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10047419/
https://www.ncbi.nlm.nih.gov/pubmed/36980241
http://dx.doi.org/10.3390/cells12060900