VEGF Stimulates Activation of ERK5 in the Absence of C-Terminal Phosphorylation Preventing Nuclear Localization and Facilitating AKT Activation in Endothelial Cells

Extracellular-signal-regulated kinase 5 (ERK5) is critical for normal cardiovascular development. Previous studies have defined a canonical pathway for ERK5 activation, showing that ligand stimulation leads to MEK5 activation resulting in dual phosphorylation of ERK5 on Thr218/Tyr220 residues within...

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Detalles Bibliográficos
Autores principales: Mondru, Anil Kumar, Aljasir, Mohammad A., Alrumayh, Ahmed, Nithianandarajah, Gopika N., Ahmed, Katie, Muller, Jurgen, Goldring, Christopher E. P., Wilm, Bettina, Cross, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10047687/
https://www.ncbi.nlm.nih.gov/pubmed/36980305
http://dx.doi.org/10.3390/cells12060967

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10047687/
https://www.ncbi.nlm.nih.gov/pubmed/36980305
http://dx.doi.org/10.3390/cells12060967

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