Identification of Dietary Bioflavonoids as Potential Inhibitors against KRAS G12D Mutant—Novel Insights from Computer-Aided Drug Discovery

The KRAS G12D mutation is very frequent in many cancers, such as pancreatic, colon and lung, and has remained undruggable for the past three decades, due to its smooth surface and lack of suitable pockets. Recent small pieces of evidence suggest that targeting the switch I/II of KRAS G12D mutant cou...

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Detalles Bibliográficos
Autores principales: Ramalingam, Prasanna Srinivasan, Balakrishnan, Purushothaman, Rajendran, Senthilnathan, Jothi, Arunachalam, Ramalingam, Rajasekaran, Arumugam, Sivakumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10047893/
https://www.ncbi.nlm.nih.gov/pubmed/36975507
http://dx.doi.org/10.3390/cimb45030137

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10047893/
https://www.ncbi.nlm.nih.gov/pubmed/36975507
http://dx.doi.org/10.3390/cimb45030137

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