Production and Characterization of K562 Cellular Clones Hyper-Expressing the Gene Encoding α-Globin: Preliminary Analysis of Biomarkers Associated with Autophagy

One of the most relevant pathophysiological hallmarks of β-thalassemia is the accumulation of toxic α-globin chains inside erythroid cells, which is responsible for their premature death (hemolysis). In this context, the availability of an experimental model system mimicking the excess in α-globin c...

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Detalles Bibliográficos
Autores principales: Zurlo, Matteo, Gasparello, Jessica, Cosenza, Lucia Carmela, Breveglieri, Giulia, Papi, Chiara, Zuccato, Cristina, Gambari, Roberto, Finotti, Alessia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10048432/
https://www.ncbi.nlm.nih.gov/pubmed/36980829
http://dx.doi.org/10.3390/genes14030556

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10048432/
https://www.ncbi.nlm.nih.gov/pubmed/36980829
http://dx.doi.org/10.3390/genes14030556

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