Cargando…

Reduced OPA1, Mitochondrial Fragmentation and Increased Susceptibility to Apoptosis in Granular Corneal Dystrophy Type 2 Corneal Fibroblasts

The progressive degeneration of granular corneal dystrophy type 2 (GCD2) corneal fibroblasts is associated with altered mitochondrial function, but the underlying mechanisms are incompletely understood. We investigated whether an imbalance of mitochondrial dynamics contributes to mitochondrial dysfu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Choi, Seung-Il, Lee, Ga-Hyun, Woo, Jong-Hwan, Jun, Ikhyun, Kim, Eung Kweon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10048436/ https://www.ncbi.nlm.nih.gov/pubmed/36980838 http://dx.doi.org/10.3390/genes14030566

Ejemplares similares

Lysosomal dysfunction of corneal fibroblasts underlies the pathogenesis of Granular Corneal Dystrophy Type 2 and can be rescued by TFEB
por: Choi, Seung‐il, et al.
Publicado: (2020)

Mitomycin C induces apoptosis in cultured corneal fibroblasts derived from type II granular corneal dystrophy corneas
por: Kim, Tae-im, et al.
Publicado: (2008)

Mini-Review: Clinical Features and Management of Granular Corneal Dystrophy Type 2
por: Chang, Myung Soo, et al.
Publicado: (2023)

Histone methylation levels correlate with TGFBIp and extracellular matrix gene expression in normal and granular corneal dystrophy type 2 corneal fibroblasts
por: Maeng, Yong-Sun, et al.
Publicado: (2015)

Compound heterozygous mutations in TGFBI cause a severe phenotype of granular corneal dystrophy type 2
por: Jun, Ikhyun, et al.
Publicado: (2021)

Extremely varied phenotypes in granular corneal dystrophy type 2 heterozygotes
por: Han, Kyung Eun, et al.
Publicado: (2012)

Comparison of the Predictive Accuracy of Intraocular Lens Power Calculations after Phototherapeutic Keratectomy in Granular Corneal Dystrophy Type 2
por: Yoon, Sook Hyun, et al.
Publicado: (2023)

Exacerbation of Granular Corneal Dystrophy Type 2 After Small Incision Lenticule Extraction
por: Kwak, Jay Jiyong, et al.
Publicado: (2021)

Corneal Higher Order Aberrations in Granular, Lattice and Macular Corneal Dystrophies
por: Yagi-Yaguchi, Yukari, et al.
Publicado: (2016)

Changes in Stress-Strain Index and Corneal Biomechanics in Granular Corneal Dystrophy
por: Heidari, Hamidreza, et al.
Publicado: (2022)

Phenotypic Spectrum of Granular Corneal Dystrophy Type II in Two Italian Families Presenting an Unusual Granular Corneal Dystrophy Type I Clinical Appearance
por: Mazzotta, Cosimo, et al.
Publicado: (2015)

Femtosecond laser-assisted cataract surgery after corneal refractive surgery
por: Ahn, Hyunmin, et al.
Publicado: (2022)

Familial association of keratoconus and granular corneal dystrophy: The familial case series
por: Cankaya, Cem, et al.
Publicado: (2018)

Corneal dystrophies
por: Klintworth, Gordon K
Publicado: (2009)

High‐throughput screening identifies suppressors of mitochondrial fragmentation in OPA1 fibroblasts
por: Cretin, Emma, et al.
Publicado: (2021)

Role of TGFBIp in Wound Healing and Mucin Expression in Corneal Epithelial Cells
por: Maeng, Yong-Sun, et al.
Publicado: (2017)

Clinical Outcomes of Small Incision Lenticule Extraction in Myopia: Study of Vector Parameters and Corneal Aberrations
por: Kwak, Jay Jiyong, et al.
Publicado: (2020)

Corneal Topography Analysis of Stromal Corneal Dystrophies
por: Kocluk, Yusuf, et al.
Publicado: (2015)

Bilateral Atypical Granular Corneal Dystrophy Associated with Unilateral Keratoconus in a Male Child
por: Dangra, Kavita Lohiya, et al.
Publicado: (2016)

Mitochondrial Dysfunction and Mitophagy in Fuchs Endothelial Corneal Dystrophy
por: Kumar, Varun, et al.
Publicado: (2021)

Femtosecond laser-assisted arcuate keratotomy for the management of corneal astigmatism in patients undergoing cataract surgery: Comparison with conventional cataract surgery
por: Ahn, Hyunmin, et al.
Publicado: (2022)

First Identification of a Triple Corneal Dystrophy Association: Keratoconus, Epithelial Basement Membrane Corneal Dystrophy and Fuchs’ Endothelial Corneal Dystrophy
por: Mazzotta, Cosimo, et al.
Publicado: (2014)

Corneal Hydration Control in Fuchs' Endothelial Corneal Dystrophy
por: Wacker, Katrin, et al.
Publicado: (2016)

Effect of Light Scattering and Higher-order Aberrations on Visual Performance in Eyes with Granular Corneal Dystrophy
por: Kamiya, Kazutaka, et al.
Publicado: (2016)

Post-LASIK exacerbation of granular corneal dystrophy type 2 in members of a chinese family
por: Chao-Shern, C, et al.
Publicado: (2018)

Repeated phototherapeutic keratectomy (PTK) followed by PTK with photorefractive keratectomy for anterior granular corneal dystrophy
por: Sridhar, Uma, et al.
Publicado: (2020)

A rare case of bilateral granular corneal dystrophy with keratoconus and primary angle closure glaucoma
por: Rajagopal, Rama, et al.
Publicado: (2022)

A Korean Patient with Lattice Corneal Dystrophy Type IV with Leu527Arg Mutation in the TGFBI Gene
por: Kim, Jinsun, et al.
Publicado: (2014)

Analysis of conjunctival fibroblasts from a proband with Schnyder corneal dystrophy
por: Mehta, Jodhbir S., et al.
Publicado: (2008)

Visual Outcomes Following Deep Anterior Lamellar Keratoplasty in Granular Corneal Dystrophy Types 1 and 2
por: uit de Bosch, Lia M, et al.
Publicado: (2016)

Adult-Onset Vitelliform Macular Dystrophy caused by BEST1 p.Ile38Ser Mutation is a Mild Form of Best Vitelliform Macular Dystrophy
por: Jun, Ikhyun, et al.
Publicado: (2017)

Stromal corneal dystrophy (possible Schnyder’s dystrophy) with peripheral corneal degeneration – diagnostic and therapeutic challenges
por: Zemba, Mihail, et al.
Publicado: (2018)

Cellular therapy of the corneal stroma: a new type of corneal surgery for keratoconus and corneal dystrophies
por: Alió del Barrio, Jorge L., et al.
Publicado: (2018)

The relationship between corneal subbasal nerve density and corneal sensitivity in patients with Fuchs endothelial corneal dystrophy
por: Dikmetas, Ozlem, et al.
Publicado: (2021)

The TGFBI R555W mutation induces a new granular corneal dystrophy type I phenotype
por: Zhu, Yanan, et al.
Publicado: (2011)

Deep anterior lamellar keratoplasty outcomes in macular and granular corneal dystrophy – A comparative cross-sectional study
por: Kodavoor, Shreesha Kumar, et al.
Publicado: (2019)

Repair of the TGFBI gene in human corneal keratocytes derived from a granular corneal dystrophy patient via CRISPR/Cas9-induced homology-directed repair
por: Taketani, Yukako, et al.
Publicado: (2017)

Concurrent Macular Corneal Dystrophy and Keratoconus
por: Mohammad-Rabei, Hossein, et al.
Publicado: (2012)

Update on the genetics of corneal endothelial dystrophies
por: Kannabiran, Chitra, et al.
Publicado: (2022)

Exclusion of known corneal dystrophy genes in an autosomal dominant pedigree of a unique anterior membrane corneal dystrophy
por: Vincent, Andrea L., et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_dlp4eljjku2jk6bg1qnrg6crhf