Identification of Three Human POLH Germline Variants Defective in Complementing the UV- and Cisplatin-Sensitivity of POLH-Deficient Cells

DNA polymerase (pol) η is responsible for error-free translesion DNA synthesis (TLS) opposite ultraviolet light (UV)-induced cis-syn cyclobutane thymine dimers (CTDs) and cisplatin-induced intrastrand guanine crosslinks. POLH deficiency causes one form of the skin cancer-prone disease xeroderma pigm...

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Detalles Bibliográficos
Autores principales: Yeom, Mina, Hong, Jin-Kyung, Shin, Joo-Ho, Lee, Yunjong, Guengerich, Frederick Peter, Choi, Jeong-Yun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10048814/
https://www.ncbi.nlm.nih.gov/pubmed/36982269
http://dx.doi.org/10.3390/ijms24065198

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10048814/
https://www.ncbi.nlm.nih.gov/pubmed/36982269
http://dx.doi.org/10.3390/ijms24065198

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