A Polyaminobiaryl-Based β-secretase Modulator Alleviates Cognitive Impairments, Amyloid Load, Astrogliosis, and Neuroinflammation in APP(Swe)/PSEN1(ΔE9) Mice Model of Amyloid Pathology

The progress in Alzheimer’s disease (AD) treatment suggests a combined therapeutic approach targeting the two lesional processes of AD, which include amyloid plaques made of toxic Aβ species and neurofibrillary tangles formed of aggregates of abnormally modified Tau proteins. A pharmacophoric design...

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Detalles Bibliográficos
Autores principales: Tautou, Marie, Descamps, Florian, Larchanché, Paul-Emmanuel, Buée, Luc, El Bakali, Jamal, Melnyk, Patricia, Sergeant, Nicolas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10048993/
https://www.ncbi.nlm.nih.gov/pubmed/36982363
http://dx.doi.org/10.3390/ijms24065285

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10048993/
https://www.ncbi.nlm.nih.gov/pubmed/36982363
http://dx.doi.org/10.3390/ijms24065285

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