Simulated Microgravity Alters P-Glycoprotein Efflux Function and Expression via the Wnt/β-Catenin Signaling Pathway in Rat Intestine and Brain

The drug efflux transporter permeability glycoprotein (P-gp) plays an important role in oral drug absorption and distribution. Under microgravity (MG), the changes in P-gp efflux function may alter the efficacy of oral drugs or lead to unexpected effects. Oral drugs are currently used to protect and...

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Detalles Bibliográficos
Autores principales: Liu, Huayan, Liang, Min, Deng, Yulin, Li, Yujuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10049079/
https://www.ncbi.nlm.nih.gov/pubmed/36982513
http://dx.doi.org/10.3390/ijms24065438

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10049079/
https://www.ncbi.nlm.nih.gov/pubmed/36982513
http://dx.doi.org/10.3390/ijms24065438

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