Timeline of changes in spike conformational dynamics in emergent SARS-CoV-2 variants reveal progressive stabilization of trimer stalk with altered NTD dynamics

SARS-CoV-2 emergent variants are characterized by increased viral fitness and each shows multiple mutations predominantly localized to the spike (S) protein. Here, amide hydrogen/deuterium exchange mass spectrometry has been applied to track changes in S dynamics from multiple SARS-CoV-2 variants. O...

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Detalles Bibliográficos
Autores principales: Braet, Sean M, Buckley, Theresa SC, Venkatakrishnan, Varun, Dam, Kim-Marie A, Bjorkman, Pamela J, Anand, Ganesh S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10049203/
https://www.ncbi.nlm.nih.gov/pubmed/36929749
http://dx.doi.org/10.7554/eLife.82584

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10049203/
https://www.ncbi.nlm.nih.gov/pubmed/36929749
http://dx.doi.org/10.7554/eLife.82584

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