Cargando…
Cryo-EM structures of an LRRC8 chimera with native functional properties reveal heptameric assembly
Volume-regulated anion channels (VRACs) mediate volume regulatory Cl(-) and organic solute efflux from vertebrate cells. VRACs are heteromeric assemblies of LRRC8A-E proteins with unknown stoichiometries. Homomeric LRRC8A and LRRC8D channels have a small pore, hexameric structure. However, these cha...
| Autores principales: | , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
eLife Sciences Publications, Ltd
2023
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10049205/ https://www.ncbi.nlm.nih.gov/pubmed/36897307 http://dx.doi.org/10.7554/eLife.82431 |