Structural insight into the stabilization of microtubules by taxanes

Paclitaxel (Taxol) is a taxane and a chemotherapeutic drug that stabilizes microtubules. While the interaction of paclitaxel with microtubules is well described, the lack of high-resolution structural information on a tubulin-taxane complex precludes a comprehensive description of the binding determ...

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Detalles Bibliográficos
Autores principales: Prota, Andrea E, Lucena-Agell, Daniel, Ma, Yuntao, Estevez-Gallego, Juan, Li, Shuo, Bargsten, Katja, Josa-Prado, Fernando, Altmann, Karl-Heinz, Gaillard, Natacha, Kamimura, Shinji, Mühlethaler, Tobias, Gago, Federico, Oliva, Maria A, Steinmetz, Michel O, Fang, Wei-Shuo, Díaz, J Fernando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10049219/
https://www.ncbi.nlm.nih.gov/pubmed/36876916
http://dx.doi.org/10.7554/eLife.84791

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10049219/
https://www.ncbi.nlm.nih.gov/pubmed/36876916
http://dx.doi.org/10.7554/eLife.84791

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