MYCN Amplification, along with Wild-Type RB1 Expression, Enhances CDK4/6 Inhibitors’ Efficacy in Neuroblastoma Cells

Neuroblastoma (NB) is one of the primary causes of death for pediatric malignancies. Given the high heterogeneity in NB’s mutation landscape, optimizing individualized therapies is still challenging. In the context of genomic alterations, MYCN amplification is the most correlated event with poor out...

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Detalles Bibliográficos
Autores principales: De Rosa, Piergiuseppe, Severi, Federica, Zadran, Suleman Khan, Russo, Marco, Aloisi, Sara, Rigamonti, Alberto, Capranico, Giovanni, Milazzo, Giorgio, Perini, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10049239/
https://www.ncbi.nlm.nih.gov/pubmed/36982482
http://dx.doi.org/10.3390/ijms24065408

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10049239/
https://www.ncbi.nlm.nih.gov/pubmed/36982482
http://dx.doi.org/10.3390/ijms24065408

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