Molecular Aspects Implicated in Dantrolene Selectivity with Respect to Ryanodine Receptor Isoforms

Dantrolene is an intra-cellularly acting skeletal muscle relaxant used for the treatment of the rare genetic disorder, malignant hyperthermia (MH). In most cases, MH susceptibility is caused by dysfunction of the skeletal ryanodine receptor (RyR1) harboring one of nearly 230 single-point MH mutation...

Descripción completa

Detalles Bibliográficos
Autores principales: Gaburjakova, Jana, Gaburjakova, Marta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10049336/
https://www.ncbi.nlm.nih.gov/pubmed/36982484
http://dx.doi.org/10.3390/ijms24065409

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10049336/
https://www.ncbi.nlm.nih.gov/pubmed/36982484
http://dx.doi.org/10.3390/ijms24065409

Ejemplares similares