Exostosin 1 Knockdown Induces Chemoresistance in MV3 Melanoma Cells by Upregulating JNK and MEK/ERK Signaling

Heparan sulfate proteoglycans (HSPGs) possess various functions driving malignancy of tumors. However, their impact on tumor cell sensitivity to cytotoxic treatment is far less understood. Aiming to investigate this, we depleted HSPGs by downregulating Exostosin 1 (EXT1), a key enzyme in HS formatio...

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Detalles Bibliográficos
Autores principales: Pfeifer, Vladlena, Weber, Heiko, Wang, Yuanyuan, Schlesinger, Martin, Gorzelanny, Christian, Bendas, Gerd
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10049486/
https://www.ncbi.nlm.nih.gov/pubmed/36982528
http://dx.doi.org/10.3390/ijms24065452

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10049486/
https://www.ncbi.nlm.nih.gov/pubmed/36982528
http://dx.doi.org/10.3390/ijms24065452

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