Cargando…

Exostosin 1 Knockdown Induces Chemoresistance in MV3 Melanoma Cells by Upregulating JNK and MEK/ERK Signaling

Heparan sulfate proteoglycans (HSPGs) possess various functions driving malignancy of tumors. However, their impact on tumor cell sensitivity to cytotoxic treatment is far less understood. Aiming to investigate this, we depleted HSPGs by downregulating Exostosin 1 (EXT1), a key enzyme in HS formatio...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pfeifer, Vladlena, Weber, Heiko, Wang, Yuanyuan, Schlesinger, Martin, Gorzelanny, Christian, Bendas, Gerd
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10049486/ https://www.ncbi.nlm.nih.gov/pubmed/36982528 http://dx.doi.org/10.3390/ijms24065452

Ejemplares similares

Mechanisms of Matrix-Induced Chemoresistance of Breast Cancer Cells—Deciphering Novel Potential Targets for a Cell Sensitization
por: Jakubzig, Bastian, et al.
Publicado: (2018)

Primary Membranous Nephropathy With Enhanced Staining of Exostosin 1/Exostosin 2 in the Glomeruli: A Report of 2 Cases
por: Iwakura, Takamasa, et al.
Publicado: (2021)

Integrin Activation Contributes to Lower Cisplatin Sensitivity in MV3 Melanoma Cells by Inducing the Wnt Signalling Pathway
por: Piva, Maria B. R., et al.
Publicado: (2017)

Prevalence of neural epidermal growth factor-like 1- and exostosin 1/exostosin 2-associated membranous nephropathy: a single-center retrospective study in Japan
por: Iwakura, Takamasa, et al.
Publicado: (2022)

The GPIb-IX complex on platelets: insight into its novel physiological functions affecting immune surveillance, hepatic thrombopoietin generation, platelet clearance and its relevance for cancer development and metastasis
por: Bendas, Gerd, et al.
Publicado: (2022)

Specific functions of Exostosin-like 3 (EXTL3) gene products
por: Yamada, Shuhei
Publicado: (2020)

A Diagnostic and Therapeutic Dilemma Concerning Exostosin 1/Exostosin 2-associated Lupus-like Membranous Nephropathy with Positive Antinuclear Antibody in an Elderly Man with Various Immune Abnormalities
por: Kawagoe, Mika, et al.
Publicado: (2023)

The Exostosin Immunohistochemical Status Differentiates Lupus Membranous Nephropathy Subsets With Different Outcomes
por: Saïdi, Michèle, et al.
Publicado: (2021)

JNK activation is essential for activation of MEK/ERK signaling in IL-1β-induced COX-2 expression in synovial fibroblasts
por: Kitanaka, Taku, et al.
Publicado: (2017)

Noxa upregulation by oncogenic activation of MEK/ERK through CREB promotes autophagy in human melanoma cells
por: Liu, Yi Lun, et al.
Publicado: (2014)

Novel exostosin-2 mutation identified in a Chinese family with hereditary multiple osteochondroma
por: Ruan, Weiwei, et al.
Publicado: (2018)

Exostosin 1 regulates cancer cell stemness in doxorubicin-resistant breast cancer cells
por: Manandhar, Sarala, et al.
Publicado: (2017)

Analysis of the Expression of Exostosins and Clinicopathological Features in Membranous Lupus Nephritis in a Chinese Cohort
por: Li, Huixian, et al.
Publicado: (2022)

Rare case of exostosin 1/exostosin 2-related membranous lupus nephritis concomitant with dual ANCA- and anti-GBM antibody-associated crescentic glomerulonephritis effectively diagnosed by mass spectrometry: a case report
por: Yamazaki, Takuya, et al.
Publicado: (2023)

Human cerebrovascular contractile receptors are upregulated via a B-Raf/MEK/ERK-sensitive signaling pathway
por: Ahnstedt, Hilda, et al.
Publicado: (2011)

Astragaloside VI Ameliorates Post-Stroke Depression via Upregulating the NRG-1-Mediated MEK/ERK Pathway
por: Chen, Xi, et al.
Publicado: (2022)

MEK/ERK addiction in CNL/aCML
por: Kesarwani, Meenu, et al.
Publicado: (2017)

No correlation between the variants of exostosin 2 gene and type 2 diabetes in Burkina Faso population
por: Ouedraogo, Serge Yannick, et al.
Publicado: (2020)

TGM2 knockdown reverses cisplatin chemoresistance in osteosarcoma
por: Li, Cuiyun, et al.
Publicado: (2018)

A Combined Activity of Thrombin and P-Selectin Is Essential for Platelet Activation by Pancreatic Cancer Cells
por: Haschemi, Reza, et al.
Publicado: (2021)

Fisetin Suppresses the Proliferation and Metastasis of Renal Cell Carcinoma through Upregulation of MEK/ERK-Targeting CTSS and ADAM9
por: Hsieh, Min-Hong, et al.
Publicado: (2019)

PSMD12 promotes the activation of the MEK-ERK pathway by upregulating KIF15 to promote the malignant progression of liver cancer
por: Zhang, Hanpu, et al.
Publicado: (2022)

CREBBP knockdown enhances RAS/RAF/MEK/ERK signaling in Ras pathway mutated acute lymphoblastic leukemia but does not modulate chemotherapeutic response
por: Dixon, Zach A., et al.
Publicado: (2017)

The structure of EXTL3 helps to explain the different roles of bi-domain exostosins in heparan sulfate synthesis
por: Wilson, L. F. L., et al.
Publicado: (2022)

A Case of Pla2r and Exostosin 1 Positive Membranous Nephropathy - The Diagnostic and Therapeutic Dilemma
por: Sivagnanam, Harish, et al.
Publicado: (2023)

Growth Inhibitory Signaling of the Raf/MEK/ERK Pathway
por: Wu, Pui-Kei, et al.
Publicado: (2020)

The MEK/ERK Module Is Reprogrammed in Remodeling Adult Cardiomyocytes
por: Thomas, Kubin, et al.
Publicado: (2020)

The MEK5/ERK5 Pathway in Health and Disease
por: Paudel, Rupesh, et al.
Publicado: (2021)

Targeting Discoidin Domain Receptor 1 (DDR1) Signaling and Its Crosstalk with β(1)-Integrin Emerges as a Key Factor for Breast Cancer Chemosensitization upon Collagen Type 1 Binding
por: Baltes, Fabian, et al.
Publicado: (2020)

The ERK and JNK pathways in the regulation of metabolic reprogramming
por: Papa, Salvatore, et al.
Publicado: (2018)

Decreased expression of miR-939 contributes to chemoresistance and metastasis of gastric cancer via dysregulation of SLC34A2 and Raf/MEK/ERK pathway
por: Zhang, Jia-Xing, et al.
Publicado: (2017)

BNIP3 upregulation via stimulation of ERK and JNK activity is required for the protection of keratinocytes from UVB-induced apoptosis
por: Moriyama, Mariko, et al.
Publicado: (2017)

Treatment of exostosin 1-associated membranous lupus nephritis with multiple low doses of rituximab: A case report
por: Li, Ling, et al.
Publicado: (2021)

Targeting transglutaminase 2 mediated exostosin glycosyltransferase 1 signaling in liver cancer stem cells with acyclic retinoid
por: Qin, Xian-Yang, et al.
Publicado: (2023)

MEK/ERK signaling pathway is required for enterovirus 71 replication in immature dendritic cells
por: Shi, Weifeng, et al.
Publicado: (2014)

Tumour cell-activated platelets modulate the immunological activity of CD4(+), CD8(+), and NK cells, which is efficiently antagonized by heparin
por: Gockel, Lukas M., et al.
Publicado: (2022)

Normal tissue doses from MV image‐guided radiation therapy (IGRT) using orthogonal MV and MV‐CBCT
por: Li, Yuting, et al.
Publicado: (2018)

Knockdown of PAF1 reduces cervical cancer cell proliferation, migration and invasion via retarding FLOT2-mediated MEK/ERK1/2 pathway
por: Tang, Bin, et al.
Publicado: (2023)

ERK1b, a 46‐kDa ERK isoform that is differentially regulated by MEK
por: Yung, Yuval, et al.
Publicado: (2022)

DGCR5 Promotes Gallbladder Cancer by Sponging MiR-3619-5p via MEK/ERK1/2 and JNK/p38 MAPK Pathways
por: Liu, Shilei, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_mjjsjfshqki9hdo3paqddef8up