Identification and Empiric Evaluation of New Inhibitors of the Multidrug Transporter P-Glycoprotein (ABCB1)

The expression of the drug efflux pump ABCB1 correlates negatively with cancer survival, making the transporter an attractive target for therapeutic inhibition. In order to identify new inhibitors of ABCB1, we have exploited the cryo-EM structure of the protein to develop a pharmacophore model deriv...

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Detalles Bibliográficos
Autores principales: Cheema, Yasmeen, Kiani, Yusra Sajid, Linton, Kenneth J., Jabeen, Ishrat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10049699/
https://www.ncbi.nlm.nih.gov/pubmed/36982374
http://dx.doi.org/10.3390/ijms24065298

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10049699/
https://www.ncbi.nlm.nih.gov/pubmed/36982374
http://dx.doi.org/10.3390/ijms24065298

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