Structural mechanism of Fab domain dissociation as a measure of interface stability

Therapeutic antibodies should not only recognize antigens specifically, but also need to be free from developability issues, such as poor stability. Thus, the mechanistic understanding and characterization of stability are critical determinants for rational antibody design. In this study, we use mol...

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Detalles Bibliográficos
Autores principales: Pomarici, Nancy D., Waibl, Franz, Quoika, Patrick K., Bujotzek, Alexander, Georges, Guy, Fernández-Quintero, Monica L., Liedl, Klaus R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10049950/
https://www.ncbi.nlm.nih.gov/pubmed/36918473
http://dx.doi.org/10.1007/s10822-023-00501-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10049950/
https://www.ncbi.nlm.nih.gov/pubmed/36918473
http://dx.doi.org/10.1007/s10822-023-00501-9

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