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Structural mechanism of Fab domain dissociation as a measure of interface stability
Therapeutic antibodies should not only recognize antigens specifically, but also need to be free from developability issues, such as poor stability. Thus, the mechanistic understanding and characterization of stability are critical determinants for rational antibody design. In this study, we use mol...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer International Publishing
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10049950/ https://www.ncbi.nlm.nih.gov/pubmed/36918473 http://dx.doi.org/10.1007/s10822-023-00501-9 |