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Norepinephrine inhibits CD8(+) T-cell infiltration and function, inducing anti-PD-1 mAb resistance in lung adenocarcinoma

BACKGROUND: Mental stress-induced neurotransmitters can affect the immune system in various ways. Therefore, a better understanding of the role of neurotransmitters in the tumour immune microenvironment is expected to promote the development of novel anti-tumour therapies. METHODS: In this study, we...

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Detalles Bibliográficos
Autores principales: Geng, Qishun, Li, Lifeng, Shen, Zhibo, Zheng, Yuanyuan, Wang, Longhao, Xue, Ruyue, Xue, Wenhua, Peng, Mengle, Zhao, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10050078/
https://www.ncbi.nlm.nih.gov/pubmed/36646807
http://dx.doi.org/10.1038/s41416-022-02132-7