Pan-cancer genomic analysis shows hemizygous PTEN loss tumors are associated with immune evasion and poor outcome

In tumors, somatic mutations of the PTEN suppressor gene are associated with advanced disease, chemotherapy resistance, and poor survival. PTEN loss of function may occur by inactivating mutation, by deletion, either affecting one copy (hemizygous loss) leading to reduced gene expression or loss of...

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Detalles Bibliográficos
Autores principales: Vidotto, T., Melo, C. M., Lautert-Dutra, W., Chaves, L. P., Reis, R. B., Squire, J. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10050165/
https://www.ncbi.nlm.nih.gov/pubmed/36977733
http://dx.doi.org/10.1038/s41598-023-31759-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10050165/
https://www.ncbi.nlm.nih.gov/pubmed/36977733
http://dx.doi.org/10.1038/s41598-023-31759-6

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