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Susceptibility of SARS COV-2 nucleocapsid and spike proteins to reactive oxygen species and role in inflammation

Chemiluminescence was used to test the susceptibility of the SARS-CoV-2 N and S proteins to oxidation by reactive oxygen species (ROS) at pH 7.4 and pH 8.5. The Fenton's system generates various ROS (H(2)O(2), (•)OH, (–)OH, (•)OOH). All proteins were found to significantly suppress oxidation (t...

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Detalles Bibliográficos
Autores principales: Pavlova, Elitsa, Genova-Kalou, Petya, Dyankov, Georgi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10050197/
https://www.ncbi.nlm.nih.gov/pubmed/36997015
http://dx.doi.org/10.1016/j.ab.2023.115137