Pyruvate kinase M2 modification by a lipid peroxidation byproduct acrolein contributes to kidney fibrosis

Renal fibrosis is a hallmark of diabetic nephropathy (DN) and is characterized by an epithelial-to-mesenchymal transition (EMT) program and aberrant glycolysis. The underlying mechanisms of renal fibrosis are still poorly understood, and existing treatments are only marginally effective. Therefore,...

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Detalles Bibliográficos
Autores principales: Kuo, Chin-Wei, Chen, Dong-Hao, Tsai, Ming-Tsun, Lin, Chih-Ching, Cheng, Hsiao-Wei, Tsay, Yeou-Guang, Wang, Hsiang-Tsui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10050374/
https://www.ncbi.nlm.nih.gov/pubmed/37007793
http://dx.doi.org/10.3389/fmed.2023.1151359

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10050374/
https://www.ncbi.nlm.nih.gov/pubmed/37007793
http://dx.doi.org/10.3389/fmed.2023.1151359

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