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Pyruvate kinase M2 modification by a lipid peroxidation byproduct acrolein contributes to kidney fibrosis
Renal fibrosis is a hallmark of diabetic nephropathy (DN) and is characterized by an epithelial-to-mesenchymal transition (EMT) program and aberrant glycolysis. The underlying mechanisms of renal fibrosis are still poorly understood, and existing treatments are only marginally effective. Therefore,...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10050374/ https://www.ncbi.nlm.nih.gov/pubmed/37007793 http://dx.doi.org/10.3389/fmed.2023.1151359 |