Structural basis of the substrate recognition and inhibition mechanism of Plasmodium falciparum nucleoside transporter PfENT1

By lacking de novo purine biosynthesis enzymes, Plasmodium falciparum requires purine nucleoside uptake from host cells. The indispensable nucleoside transporter ENT1 of P. falciparum facilitates nucleoside uptake in the asexual blood stage. Specific inhibitors of PfENT1 prevent the proliferation of...

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Detalles Bibliográficos
Autores principales: Wang, Chen, Yu, Leiye, Zhang, Jiying, Zhou, Yanxia, Sun, Bo, Xiao, Qingjie, Zhang, Minhua, Liu, Huayi, Li, Jinhong, Li, Jialu, Luo, Yunzi, Xu, Jie, Lian, Zhong, Lin, Jingwen, Wang, Xiang, Zhang, Peng, Guo, Li, Ren, Ruobing, Deng, Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10050424/
https://www.ncbi.nlm.nih.gov/pubmed/36977719
http://dx.doi.org/10.1038/s41467-023-37411-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10050424/
https://www.ncbi.nlm.nih.gov/pubmed/36977719
http://dx.doi.org/10.1038/s41467-023-37411-1

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