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Syk inhibitors protect against microglia-mediated neuronal loss in culture

Microglia are brain macrophages and play beneficial and/or detrimental roles in many brain pathologies because of their inflammatory and phagocytic activity. Microglial inflammation and phagocytosis are thought to be regulated by spleen tyrosine kinase (Syk), which is activated by multiple microglia...

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Detalles Bibliográficos
Autores principales: Birkle, Timothy J. Y., Brown, Guy C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10050448/
https://www.ncbi.nlm.nih.gov/pubmed/37009452
http://dx.doi.org/10.3389/fnagi.2023.1120952