Cargando…

T-cell exhaustion signatures characterize the immune landscape and predict HCC prognosis via integrating single-cell RNA-seq and bulk RNA-sequencing

BACKGROUND: Hepatocellular carcinoma (HCC), the third most prevalent cause of cancer-related death, is a frequent primary liver cancer with a high rate of morbidity and mortality. T-cell depletion (TEX) is a progressive decline in T-cell function due to continuous stimulation of the TCR in the prese...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chi, Hao, Zhao, Songyun, Yang, Jinyan, Gao, Xinrui, Peng, Gaoge, Zhang, Jinhao, Xie, Xixi, Song, Guobin, Xu, Ke, Xia, Zhijia, Chen, Shi, Zhao, Jinqiu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10050519/ https://www.ncbi.nlm.nih.gov/pubmed/37006257 http://dx.doi.org/10.3389/fimmu.2023.1137025

Ejemplares similares

CD8 + T-cell marker genes reveal different immune subtypes of oral lichen planus by integrating single-cell RNA-seq and bulk RNA-sequencing
por: Zhang, Jinhao, et al.
Publicado: (2023)

Machine learning to construct sphingolipid metabolism genes signature to characterize the immune landscape and prognosis of patients with uveal melanoma
por: Chi, Hao, et al.
Publicado: (2022)

Natural killer cell-related prognosis signature characterizes immune landscape and predicts prognosis of HNSCC
por: Chi, Hao, et al.
Publicado: (2022)

Single‐cell RNA‐seq and bulk RNA‐seq explore the prognostic value of exhausted T cells in hepatocellular carcinoma
por: Tang, Xiaolong, et al.
Publicado: (2023)

Identification and validation of neurotrophic factor-related genes signature in HNSCC to predict survival and immune landscapes
por: Peng, Gaoge, et al.
Publicado: (2022)

Circadian rhythm-related genes index: A predictor for HNSCC prognosis, immunotherapy efficacy, and chemosensitivity
por: Chi, Hao, et al.
Publicado: (2023)

Cuprotosis Programmed-Cell-Death-Related lncRNA Signature Predicts Prognosis and Immune Landscape in PAAD Patients
por: Chi, Hao, et al.
Publicado: (2022)

SCRABBLE: single-cell RNA-seq imputation constrained by bulk RNA-seq data
por: Peng, Tao, et al.
Publicado: (2019)

Integrating single-cell RNA-seq and bulk RNA-seq to construct prognostic signatures to explore the role of glutamine metabolism in breast cancer
por: Pei, Shengbin, et al.
Publicado: (2023)

Uncovering the potential role of oxidative stress in the development of periodontitis and establishing a stable diagnostic model via combining single-cell and machine learning analysis
por: Song, Guobin, et al.
Publicado: (2023)

Deep learning using bulk RNA-seq data expands cell landscape identification in tumor microenvironment
por: Wang, Xin, et al.
Publicado: (2022)

Integrative Analysis of Bulk RNA-Seq and Single-Cell RNA-Seq Unveils Novel Prognostic Biomarkers in Multiple Myeloma
por: Zhao, Jing, et al.
Publicado: (2022)

Single-Cell RNA-Seq and Bulk RNA-Seq Reveal Intratumoral Heterogeneity and Tumor Microenvironment Characteristics in Diffuse Large B-Cell Lymphoma
por: Zhao, Yang, et al.
Publicado: (2022)

An Efficient and Flexible Method for Deconvoluting Bulk RNA-Seq Data with Single-Cell RNA-Seq Data
por: Sun, Xifang, et al.
Publicado: (2019)

Integrative Analysis of Bulk RNA-Seq and Single-Cell RNA-Seq Unveils the Characteristics of the Immune Microenvironment and Prognosis Signature in Prostate Cancer
por: Wang, Ruisong, et al.
Publicado: (2022)

ScRNA-seq and bulk RNA-seq reveal the characteristics of ferroptosis and establish a risk signature in cholangiocarcinoma
por: Yao, Wenchao, et al.
Publicado: (2022)

Effective methods for bulk RNA-seq deconvolution using scnRNA-seq transcriptomes
por: Cobos, Francisco Avila, et al.
Publicado: (2023)

Integration of scRNA-Seq and bulk RNA-Seq uncover perturbed immune cell types and pathways of Kawasaki disease
por: Cao, Naixin, et al.
Publicado: (2023)

Integrated analysis of single-cell RNA-seq and bulk RNA-seq unravels the heterogeneity of cancer-associated fibroblasts in TNBC
por: Wu, Xiaoqing, et al.
Publicado: (2023)

Gene Mapping via Bulked Segregant RNA-Seq (BSR-Seq)
por: Liu, Sanzhen, et al.
Publicado: (2012)

Combined bulk RNA-seq and single-cell RNA-seq identifies a necroptosis-related prognostic signature associated with inhibitory immune microenvironment in glioma
por: Wan, Sicheng, et al.
Publicado: (2022)

Construction of cancer- associated fibroblasts related risk signature based on single-cell RNA-seq and bulk RNA-seq data in bladder urothelial carcinoma
por: Liu, Yunxun, et al.
Publicado: (2023)

Mast cell marker gene signature: prognosis and immunotherapy response prediction in lung adenocarcinoma through integrated scRNA-seq and bulk RNA-seq
por: Zhang, Pengpeng, et al.
Publicado: (2023)

Prognosis and therapeutic benefits prediction based on NK cell marker genes through single-cell RNA-seq with integrated bulk RNA-seq analysis for hepatocellular carcinoma
por: Yang, Yao, et al.
Publicado: (2023)

Combination of single-cell and bulk RNA seq reveals the immune infiltration landscape and targeted therapeutic drugs in spinal cord injury
por: Zhang, Qing, et al.
Publicado: (2023)

Expression of hub genes of endothelial cells in glioblastoma-A prognostic model for GBM patients integrating single-cell RNA sequencing and bulk RNA sequencing
por: Zhao, Songyun, et al.
Publicado: (2022)

Single cell RNA-seq analysis identifies a noncoding RNA mediating resistance to sorafenib treatment in HCC
por: Zhou, Kevin, et al.
Publicado: (2022)

A Survey on Methods for Predicting Polyadenylation Sites from DNA Sequences, Bulk RNA-seq, and Single-cell RNA-seq
por: Ye, Wenbin, et al.
Publicado: (2023)

Prime-seq, efficient and powerful bulk RNA sequencing
por: Janjic, Aleksandar, et al.
Publicado: (2022)

Integrated Analysis of Single-Cell RNA-Seq and Bulk RNA-Seq Combined with Multiple Machine Learning Identified a Novel Immune Signature in Diabetic Nephropathy
por: Peng, Yue-Ling, et al.
Publicado: (2023)

Modeling group heteroscedasticity in single-cell RNA-seq pseudo-bulk data
por: You, Yue, et al.
Publicado: (2023)

Integrated analysis of single-cell RNA-seq and bulk RNA-seq reveals RNA N6-methyladenosine modification associated with prognosis and drug resistance in acute myeloid leukemia
por: Li, Zhongzheng, et al.
Publicado: (2023)

RNA-Seq Technology Reveals the Mechanism of SDT Combined With Novel Nanobubbles Against HCC
por: Shang, Haitao, et al.
Publicado: (2022)

Exploring PANoptosis in breast cancer based on scRNA-seq and bulk-seq
por: He, Puxing, et al.
Publicado: (2023)

Analysis on heterogeneity of hepatocellular carcinoma immune cells and a molecular risk model by integration of scRNA-seq and bulk RNA-seq
por: Liu, Xiaorui, et al.
Publicado: (2022)

Integrating Single-Cell RNA-Seq and Bulk RNA-Seq Data to Explore the Key Role of Fatty Acid Metabolism in Breast Cancer
por: Chen, Yongxing, et al.
Publicado: (2023)

Characterization of cancer-related fibroblasts (CAF) in hepatocellular carcinoma and construction of CAF-based risk signature based on single-cell RNA-seq and bulk RNA-seq data
por: Yu, Lianghe, et al.
Publicado: (2022)

Integrated analysis of single-cell RNA-seq and bulk RNA-seq unveils heterogeneity and establishes a novel signature for prognosis and tumor immune microenvironment in ovarian cancer
por: Wang, Zitao, et al.
Publicado: (2023)

Integrated analysis of single-cell and bulk RNA-seq establishes a novel signature for prediction in gastric cancer
por: Wen, Fei, et al.
Publicado: (2023)

BingleSeq: a user-friendly R package for bulk and single-cell RNA-Seq data analysis
por: Dimitrov, Daniel, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_v0rji6fg77pscjd2hmmevfqbfj