CRISPRi-mediated characterization of novel anti-tuberculosis targets: Mycobacterial peptidoglycan modifications promote beta-lactam resistance and intracellular survival

The lack of effective therapeutics against emerging multi-drug resistant strains of Mycobacterium tuberculosis (Mtb) prompts the identification of novel anti-tuberculosis targets. The essential nature of the peptidoglycan (PG) layer of the mycobacterial cell wall, which features several distinctive...

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Detalles Bibliográficos
Autores principales: Silveiro, Cátia, Marques, Mariana, Olivença, Francisco, Pires, David, Mortinho, Diana, Nunes, Alexandra, Pimentel, Madalena, Anes, Elsa, Catalão, Maria João
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Cellular and Infection Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10050696/
https://www.ncbi.nlm.nih.gov/pubmed/37009497
http://dx.doi.org/10.3389/fcimb.2023.1089911

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10050696/
https://www.ncbi.nlm.nih.gov/pubmed/37009497
http://dx.doi.org/10.3389/fcimb.2023.1089911

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