RNA silencing of GM-CSF in CAR-T cells reduces the secretion of multiple inflammatory cytokines

Chimeric antigen receptor T (CAR-T) cell therapy has become a research hotspot in the field of hematological malignancies. However, CAR-T cell therapy can lead to immunotherapy-associated side effects including cytokine release syndrome and neurotoxicity. Gene depletion of GM-CSF in CAR-T cells was...

Descripción completa

Detalles Bibliográficos
Autores principales: Shang, Siqi, Chen, Yunshuo, Yang, Xuejiao, Yang, Ying, Wang, Wenbo, Wang, Yueying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10050814/
https://www.ncbi.nlm.nih.gov/pubmed/36988829
http://dx.doi.org/10.1007/s10637-023-01344-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10050814/
https://www.ncbi.nlm.nih.gov/pubmed/36988829
http://dx.doi.org/10.1007/s10637-023-01344-9

Ejemplares similares