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RNA silencing of GM-CSF in CAR-T cells reduces the secretion of multiple inflammatory cytokines

Chimeric antigen receptor T (CAR-T) cell therapy has become a research hotspot in the field of hematological malignancies. However, CAR-T cell therapy can lead to immunotherapy-associated side effects including cytokine release syndrome and neurotoxicity. Gene depletion of GM-CSF in CAR-T cells was...

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Detalles Bibliográficos
Autores principales:	Shang, Siqi, Chen, Yunshuo, Yang, Xuejiao, Yang, Ying, Wang, Wenbo, Wang, Yueying
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer US 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10050814/ https://www.ncbi.nlm.nih.gov/pubmed/36988829 http://dx.doi.org/10.1007/s10637-023-01344-9

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