Transgenic mice overexpressing mutant TDP-43 show aberrant splicing of neurological disorders-associated gene Zmynd11 prior to onset of motor symptoms

Mutations in TDP-43 are known to cause Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD). TDP-43 binds to and regulates splicing of several RNA including Zmynd11 . Zmynd11 is a transcriptional repressor and a potential E3 ubiquitin ligase family member, known for its role in neur...

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Detalles Bibliográficos
Autores principales: Narayanan, Ramesh K., Panwar, Ajay, Butler, Tim J., Cutrupi, Anthony N., Kennerson, Marina, Vucic, Steve, Ashokkumar, Balasubramaniem, Mangelsdorf, Marie, Wallace, Robyn H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Caltech Library 2023
Materias:
New Finding
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10051033/
https://www.ncbi.nlm.nih.gov/pubmed/37008727
http://dx.doi.org/10.17912/micropub.biology.000777

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10051033/
https://www.ncbi.nlm.nih.gov/pubmed/37008727
http://dx.doi.org/10.17912/micropub.biology.000777

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