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Alone and together: current approaches to targeting glutaminase enzymes as part of anti-cancer therapies
Metabolic reprogramming is a major hallmark of malignant transformation in cancer, and part of the so-called Warburg effect, in which the upregulation of glutamine catabolism plays a major role. The glutaminase enzymes convert glutamine to glutamate, which initiates this pathway. Inhibition of diffe...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Newlands Press Ltd
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10051075/ https://www.ncbi.nlm.nih.gov/pubmed/37009252 http://dx.doi.org/10.4155/fdd-2022-0011 |