Structure and Dynamics of Three Escherichia coli NfsB Nitro-Reductase Mutants Selected for Enhanced Activity with the Cancer Prodrug CB1954

Escherichia coli NfsB has been studied extensively for its potential for cancer gene therapy by reducing the prodrug CB1954 to a cytotoxic derivative. We have previously made several mutants with enhanced activity for the prodrug and characterised their activity in vitro and in vivo. Here, we determ...

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Detalles Bibliográficos
Autores principales: Day, Martin A., Christofferson, Andrew J., Anderson, J. L. Ross, Vass, Simon O., Evans, Adam, Searle, Peter F., White, Scott A., Hyde, Eva I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10051150/
https://www.ncbi.nlm.nih.gov/pubmed/36983061
http://dx.doi.org/10.3390/ijms24065987

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10051150/
https://www.ncbi.nlm.nih.gov/pubmed/36983061
http://dx.doi.org/10.3390/ijms24065987

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