Human Polβ Natural Polymorphic Variants G118V and R149I Affects Substate Binding and Catalysis

DNA polymerase β (Polβ) expression is essential for the cell’s response to DNA damage that occurs during natural cellular processes. Polβ is considered the main reparative DNA polymerase, whose role is to fill the DNA gaps arising in the base excision repair pathway. Mutations in Polβ can lead to ca...

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Detalles Bibliográficos
Autores principales: Kladova, Olga A., Tyugashev, Timofey E., Mikushina, Elena S., Soloviev, Nikita O., Kuznetsov, Nikita A., Novopashina, Daria S., Kuznetsova, Aleksandra A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10051265/
https://www.ncbi.nlm.nih.gov/pubmed/36982964
http://dx.doi.org/10.3390/ijms24065892

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10051265/
https://www.ncbi.nlm.nih.gov/pubmed/36982964
http://dx.doi.org/10.3390/ijms24065892

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