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Safety and Feasibility of Analgosedation for Electrochemotherapy of Liver Lesions
Interventional Oncology treatments grant low-risk mini-invasive alternatives to surgery for cancer patients. Percutaneous ablative therapies represent a cornerstone for treatment of liver cancer patients. Among these, a newly emerging one is represented by electrochemotherapy. Improvements in analge...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10051269/ https://www.ncbi.nlm.nih.gov/pubmed/36983788 http://dx.doi.org/10.3390/life13030631 |
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author | Iezzi, Roberto Posa, Alessandro Caputo, Cosimo Tommaso De Leoni, Davide Sbaraglia, Fabio Rossi, Marco Tortora, Giampaolo Tagliaferri, Luca Valentini, Vincenzo Colosimo, Cesare |
author_facet | Iezzi, Roberto Posa, Alessandro Caputo, Cosimo Tommaso De Leoni, Davide Sbaraglia, Fabio Rossi, Marco Tortora, Giampaolo Tagliaferri, Luca Valentini, Vincenzo Colosimo, Cesare |
author_sort | Iezzi, Roberto |
collection | PubMed |
description | Interventional Oncology treatments grant low-risk mini-invasive alternatives to surgery for cancer patients. Percutaneous ablative therapies represent a cornerstone for treatment of liver cancer patients. Among these, a newly emerging one is represented by electrochemotherapy. Improvements in analgesia and sedation can nowadays offer optimal support for ablative procedures, serving as a valid alternative to general anesthesia. The intention of this retrospective monocentric study is to report our preliminary experience on feasibility and safety of electrochemotherapy for treatment of complex liver tumors unfit for thermal ablation, using analgosedation instead of general anesthesia. Five patients were enrolled in the study, undergoing electrochemotherapy under analgosedation. Mean procedural time and hospitalization time were recorded. Immediate post-procedural cone-beam CT showed complete coverage of the lesion without complications. One-month CT examination showed an overall response rate of 100% (four complete responses, one partial response). Electrochemotherapy under analgosedation seems to be a safe, feasible, and effective option for liver cancer patients not amenable to other ablative techniques. |
format | Online Article Text |
id | pubmed-10051269 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100512692023-03-30 Safety and Feasibility of Analgosedation for Electrochemotherapy of Liver Lesions Iezzi, Roberto Posa, Alessandro Caputo, Cosimo Tommaso De Leoni, Davide Sbaraglia, Fabio Rossi, Marco Tortora, Giampaolo Tagliaferri, Luca Valentini, Vincenzo Colosimo, Cesare Life (Basel) Communication Interventional Oncology treatments grant low-risk mini-invasive alternatives to surgery for cancer patients. Percutaneous ablative therapies represent a cornerstone for treatment of liver cancer patients. Among these, a newly emerging one is represented by electrochemotherapy. Improvements in analgesia and sedation can nowadays offer optimal support for ablative procedures, serving as a valid alternative to general anesthesia. The intention of this retrospective monocentric study is to report our preliminary experience on feasibility and safety of electrochemotherapy for treatment of complex liver tumors unfit for thermal ablation, using analgosedation instead of general anesthesia. Five patients were enrolled in the study, undergoing electrochemotherapy under analgosedation. Mean procedural time and hospitalization time were recorded. Immediate post-procedural cone-beam CT showed complete coverage of the lesion without complications. One-month CT examination showed an overall response rate of 100% (four complete responses, one partial response). Electrochemotherapy under analgosedation seems to be a safe, feasible, and effective option for liver cancer patients not amenable to other ablative techniques. MDPI 2023-02-24 /pmc/articles/PMC10051269/ /pubmed/36983788 http://dx.doi.org/10.3390/life13030631 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Communication Iezzi, Roberto Posa, Alessandro Caputo, Cosimo Tommaso De Leoni, Davide Sbaraglia, Fabio Rossi, Marco Tortora, Giampaolo Tagliaferri, Luca Valentini, Vincenzo Colosimo, Cesare Safety and Feasibility of Analgosedation for Electrochemotherapy of Liver Lesions |
title | Safety and Feasibility of Analgosedation for Electrochemotherapy of Liver Lesions |
title_full | Safety and Feasibility of Analgosedation for Electrochemotherapy of Liver Lesions |
title_fullStr | Safety and Feasibility of Analgosedation for Electrochemotherapy of Liver Lesions |
title_full_unstemmed | Safety and Feasibility of Analgosedation for Electrochemotherapy of Liver Lesions |
title_short | Safety and Feasibility of Analgosedation for Electrochemotherapy of Liver Lesions |
title_sort | safety and feasibility of analgosedation for electrochemotherapy of liver lesions |
topic | Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10051269/ https://www.ncbi.nlm.nih.gov/pubmed/36983788 http://dx.doi.org/10.3390/life13030631 |
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