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Safety and Feasibility of Analgosedation for Electrochemotherapy of Liver Lesions

Interventional Oncology treatments grant low-risk mini-invasive alternatives to surgery for cancer patients. Percutaneous ablative therapies represent a cornerstone for treatment of liver cancer patients. Among these, a newly emerging one is represented by electrochemotherapy. Improvements in analge...

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Autores principales: Iezzi, Roberto, Posa, Alessandro, Caputo, Cosimo Tommaso, De Leoni, Davide, Sbaraglia, Fabio, Rossi, Marco, Tortora, Giampaolo, Tagliaferri, Luca, Valentini, Vincenzo, Colosimo, Cesare
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10051269/
https://www.ncbi.nlm.nih.gov/pubmed/36983788
http://dx.doi.org/10.3390/life13030631
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author Iezzi, Roberto
Posa, Alessandro
Caputo, Cosimo Tommaso
De Leoni, Davide
Sbaraglia, Fabio
Rossi, Marco
Tortora, Giampaolo
Tagliaferri, Luca
Valentini, Vincenzo
Colosimo, Cesare
author_facet Iezzi, Roberto
Posa, Alessandro
Caputo, Cosimo Tommaso
De Leoni, Davide
Sbaraglia, Fabio
Rossi, Marco
Tortora, Giampaolo
Tagliaferri, Luca
Valentini, Vincenzo
Colosimo, Cesare
author_sort Iezzi, Roberto
collection PubMed
description Interventional Oncology treatments grant low-risk mini-invasive alternatives to surgery for cancer patients. Percutaneous ablative therapies represent a cornerstone for treatment of liver cancer patients. Among these, a newly emerging one is represented by electrochemotherapy. Improvements in analgesia and sedation can nowadays offer optimal support for ablative procedures, serving as a valid alternative to general anesthesia. The intention of this retrospective monocentric study is to report our preliminary experience on feasibility and safety of electrochemotherapy for treatment of complex liver tumors unfit for thermal ablation, using analgosedation instead of general anesthesia. Five patients were enrolled in the study, undergoing electrochemotherapy under analgosedation. Mean procedural time and hospitalization time were recorded. Immediate post-procedural cone-beam CT showed complete coverage of the lesion without complications. One-month CT examination showed an overall response rate of 100% (four complete responses, one partial response). Electrochemotherapy under analgosedation seems to be a safe, feasible, and effective option for liver cancer patients not amenable to other ablative techniques.
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spelling pubmed-100512692023-03-30 Safety and Feasibility of Analgosedation for Electrochemotherapy of Liver Lesions Iezzi, Roberto Posa, Alessandro Caputo, Cosimo Tommaso De Leoni, Davide Sbaraglia, Fabio Rossi, Marco Tortora, Giampaolo Tagliaferri, Luca Valentini, Vincenzo Colosimo, Cesare Life (Basel) Communication Interventional Oncology treatments grant low-risk mini-invasive alternatives to surgery for cancer patients. Percutaneous ablative therapies represent a cornerstone for treatment of liver cancer patients. Among these, a newly emerging one is represented by electrochemotherapy. Improvements in analgesia and sedation can nowadays offer optimal support for ablative procedures, serving as a valid alternative to general anesthesia. The intention of this retrospective monocentric study is to report our preliminary experience on feasibility and safety of electrochemotherapy for treatment of complex liver tumors unfit for thermal ablation, using analgosedation instead of general anesthesia. Five patients were enrolled in the study, undergoing electrochemotherapy under analgosedation. Mean procedural time and hospitalization time were recorded. Immediate post-procedural cone-beam CT showed complete coverage of the lesion without complications. One-month CT examination showed an overall response rate of 100% (four complete responses, one partial response). Electrochemotherapy under analgosedation seems to be a safe, feasible, and effective option for liver cancer patients not amenable to other ablative techniques. MDPI 2023-02-24 /pmc/articles/PMC10051269/ /pubmed/36983788 http://dx.doi.org/10.3390/life13030631 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Iezzi, Roberto
Posa, Alessandro
Caputo, Cosimo Tommaso
De Leoni, Davide
Sbaraglia, Fabio
Rossi, Marco
Tortora, Giampaolo
Tagliaferri, Luca
Valentini, Vincenzo
Colosimo, Cesare
Safety and Feasibility of Analgosedation for Electrochemotherapy of Liver Lesions
title Safety and Feasibility of Analgosedation for Electrochemotherapy of Liver Lesions
title_full Safety and Feasibility of Analgosedation for Electrochemotherapy of Liver Lesions
title_fullStr Safety and Feasibility of Analgosedation for Electrochemotherapy of Liver Lesions
title_full_unstemmed Safety and Feasibility of Analgosedation for Electrochemotherapy of Liver Lesions
title_short Safety and Feasibility of Analgosedation for Electrochemotherapy of Liver Lesions
title_sort safety and feasibility of analgosedation for electrochemotherapy of liver lesions
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10051269/
https://www.ncbi.nlm.nih.gov/pubmed/36983788
http://dx.doi.org/10.3390/life13030631
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