Neoprzewaquinone A Inhibits Breast Cancer Cell Migration and Promotes Smooth Muscle Relaxation by Targeting PIM1 to Block ROCK2/STAT3 Pathway

Salvia miltiorrhiza Bunge (Danshen) has been widely used to treat cancer and cardiovascular diseases in Chinese traditional medicine. Here, we found that Neoprzewaquinone A (NEO), an active component of S. miltiorrhiza, selectively inhibits PIM1. We showed that NEO potently inhibits PIM1 kinase at n...

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Detalles Bibliográficos
Autores principales: Zhao, Guiying, Ren, Yali, Yan, Jie, Zhang, Tingrui, Lu, Peng, Lei, Jieting, Rao, Huanan, Kang, Xin, Cao, Zhixing, Peng, Fu, Peng, Cheng, Rao, Chaolong, Li, Yuzhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10051292/
https://www.ncbi.nlm.nih.gov/pubmed/36982538
http://dx.doi.org/10.3390/ijms24065464

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10051292/
https://www.ncbi.nlm.nih.gov/pubmed/36982538
http://dx.doi.org/10.3390/ijms24065464

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