Molecular Mechanisms of Deregulation of Muscle Contractility Caused by the R168H Mutation in TPM3 and Its Attenuation by Therapeutic Agents

The substitution for Arg168His (R168H) in γ-tropomyosin (TPM3 gene, Tpm3.12 isoform) is associated with congenital muscle fiber type disproportion (CFTD) and muscle weakness. It is still unclear what molecular mechanisms underlie the muscle dysfunction seen in CFTD. The aim of this work was to study...

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Detalles Bibliográficos
Autores principales: Karpicheva, Olga E., Avrova, Stanislava V., Bogdanov, Andrey L., Sirenko, Vladimir V., Redwood, Charles S., Borovikov, Yurii S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10051413/
https://www.ncbi.nlm.nih.gov/pubmed/36982903
http://dx.doi.org/10.3390/ijms24065829

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10051413/
https://www.ncbi.nlm.nih.gov/pubmed/36982903
http://dx.doi.org/10.3390/ijms24065829

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