Suramin Disturbs the Association of the N-Terminal Domain of SARS-CoV-2 Nucleocapsid Protein with RNA

Suramin was originally used as an antiparasitic drug in clinics. Here, we demonstrate that suramin can bind to the N-terminal domain of SARS-CoV-2 nucleocapsid protein (N-NTD) and disturb its interaction with RNA. The BLI experiments showed that N-NTD interacts suramin with a dissociate constant (K(...

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Detalles Bibliográficos
Autores principales: Guo, Chenyun, Xu, Hao, Li, Xiao, Yu, Jiaxin, Lin, Donghai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10051649/
https://www.ncbi.nlm.nih.gov/pubmed/36985506
http://dx.doi.org/10.3390/molecules28062534

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10051649/
https://www.ncbi.nlm.nih.gov/pubmed/36985506
http://dx.doi.org/10.3390/molecules28062534

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