CDR3 Variants of the TXB2 Shuttle with Increased TfR1 Association Rate and Enhanced Brain Penetration

Since the delivery of biologic drugs to the brain is greatly hampered by the existence of the blood–brain barrier (BBB), brain shuttles are being developed to enhance therapeutic efficacy. As we have previously shown, efficient and selective brain delivery was achieved with TXB2, a cross-species rea...

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Detalles Bibliográficos
Autores principales: Stocki, Pawel, Szary, Jaroslaw, Demydchuk, Mykhaylo, Northall, Leandra, Rasmussen, Charlotte L. M., Logan, Diana Bahu, Gauhar, Aziz, Thei, Laura, Coker, Shu-Fen, Moos, Torben, Walsh, Frank S., Rutkowski, J. Lynn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10051654/
https://www.ncbi.nlm.nih.gov/pubmed/36986599
http://dx.doi.org/10.3390/pharmaceutics15030739

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10051654/
https://www.ncbi.nlm.nih.gov/pubmed/36986599
http://dx.doi.org/10.3390/pharmaceutics15030739

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