A Validated Chiral LC–MS/MS Method for the Enantioselective Determination of (S)-(+)- and (R)-(-)-Ibuprofen in Dog Plasma: Its Application to a Pharmacokinetic Study

The purpose of this study was to develop a method for simultaneously separating ibuprofen enantiomers using electrospray ionization (ESI) liquid chromatography with tandem mass spectrometry (LC–MS/MS). LC–MS/MS was operated with negative ionization and multiple reaction monitoring modes; transitions...

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Detalles Bibliográficos
Autores principales: Choi, Sanghee, Shim, Wang-Seob, Yoon, Jiyoung, Choi, Doowon, Lee, Jinseong, Paik, Soo-Heui, Chung, Eun-Kyoung, Lee, Kyung-Tae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10051808/
https://www.ncbi.nlm.nih.gov/pubmed/36986684
http://dx.doi.org/10.3390/pharmaceutics15030824

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10051808/
https://www.ncbi.nlm.nih.gov/pubmed/36986684
http://dx.doi.org/10.3390/pharmaceutics15030824

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