Differential Preincubation Effects of Nicardipine on OATP1B1- and OATP1B3-Mediated Transport in the Presence and Absence of Protein: Implications in Assessing OATP1B1- and OATP1B3-Mediated Drug–Drug Interactions

Impaired transport activity of hepatic OATP1B1 and OATP1B3 due to drug–drug interactions (DDIs) often leads to increased systemic exposure to substrate drugs (e.g., lipid-lowering statins). Since dyslipidemia and hypertension frequently coexist, statins are often concurrently used with antihypertens...

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Detalles Bibliográficos
Autores principales: Kayesh, Ruhul, Tambe, Vishakha, Xu, Chao, Yue, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10052025/
https://www.ncbi.nlm.nih.gov/pubmed/36986880
http://dx.doi.org/10.3390/pharmaceutics15031020

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10052025/
https://www.ncbi.nlm.nih.gov/pubmed/36986880
http://dx.doi.org/10.3390/pharmaceutics15031020

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