Enhanced Remdesivir Analogues to Target SARS-CoV-2

We report the short synthesis of novel C-nucleoside Remdesivir analogues, their cytotoxicity and an in vitro evaluation against SARS-CoV-2 (CoV2). The described compounds are nucleoside analogues bearing a nitrogen heterocycle as purine analogues. The hybrid structures described herein are designed...

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Detalles Bibliográficos
Autores principales: Majima, Ryuichi, Edwards, Tiffany C., Dreis, Christine D., Geraghty, Robert J., Bonnac, Laurent F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10052049/
https://www.ncbi.nlm.nih.gov/pubmed/36985586
http://dx.doi.org/10.3390/molecules28062616

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10052049/
https://www.ncbi.nlm.nih.gov/pubmed/36985586
http://dx.doi.org/10.3390/molecules28062616

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