Correlative Chemical Imaging and Spatial Chemometrics Delineate Alzheimer Plaque Heterogeneity at High Spatial Resolution

[Image: see text] We present a novel, correlative chemical imaging strategy based on multimodal matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging (MSI), hyperspectral microscopy, and spatial chemometrics. Our workflow overcomes challenges associated with correlative MSI d...

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Detalles Bibliográficos
Autores principales: Wehrli, Patrick M., Ge, Junyue, Michno, Wojciech, Koutarapu, Srinivas, Dreos, Ambra, Jha, Durga, Zetterberg, Henrik, Blennow, Kaj, Hanrieder, Jörg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10052239/
https://www.ncbi.nlm.nih.gov/pubmed/37006756
http://dx.doi.org/10.1021/jacsau.2c00492

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10052239/
https://www.ncbi.nlm.nih.gov/pubmed/37006756
http://dx.doi.org/10.1021/jacsau.2c00492

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