Transfer learning identifies sequence determinants of cell-type specific regulatory element accessibility

Dysfunction of regulatory elements through genetic variants is a central mechanism in the pathogenesis of disease. To better understand disease etiology, there is consequently a need to understand how DNA encodes regulatory activity. Deep learning methods show great promise for modeling of biomolecu...

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Detalles Bibliográficos
Autores principales: Salvatore, Marco, Horlacher, Marc, Marsico, Annalisa, Winther, Ole, Andersson, Robin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Standard Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10052367/
https://www.ncbi.nlm.nih.gov/pubmed/37007588
http://dx.doi.org/10.1093/nargab/lqad026

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10052367/
https://www.ncbi.nlm.nih.gov/pubmed/37007588
http://dx.doi.org/10.1093/nargab/lqad026

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