Silver Nanoparticles and Their Therapeutic Applications in Endodontics: A Narrative Review
The efficient elimination of microorganisms and their byproducts from infected root canals is compromised by the limitations in conventional root canal disinfection strategies and antimicrobials. Silver nanoparticles (AgNPs) are advantageous for root canal disinfection, mainly due to their wide-spec...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10052550/ https://www.ncbi.nlm.nih.gov/pubmed/36986576 http://dx.doi.org/10.3390/pharmaceutics15030715 |
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author | Afkhami, Farzaneh Forghan, Parisa Gutmann, James L. Kishen, Anil |
author_facet | Afkhami, Farzaneh Forghan, Parisa Gutmann, James L. Kishen, Anil |
author_sort | Afkhami, Farzaneh |
collection | PubMed |
description | The efficient elimination of microorganisms and their byproducts from infected root canals is compromised by the limitations in conventional root canal disinfection strategies and antimicrobials. Silver nanoparticles (AgNPs) are advantageous for root canal disinfection, mainly due to their wide-spectrum anti-microbial activity. Compared to other commonly used nanoparticulate antibacterials, AgNPs have acceptable antibacterial properties and relatively low cytotoxicity. Owing to their nano-scale, AgNPs penetrate deeper into the complexities of the root canal systems and dentinal tubules, as well as enhancing the antibacterial properties of endodontic irrigants and sealers. AgNPs gradually increase the dentin hardness in endodontically treated teeth and promote antibacterial properties when used as a carrier for intracanal medication. The unique properties of AgNPs make them an ideal additive for different endodontic biomaterials. However, the possible side effects of AgNPs, such as cytotoxicity and tooth discoloration potential, merits further research. |
format | Online Article Text |
id | pubmed-10052550 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100525502023-03-30 Silver Nanoparticles and Their Therapeutic Applications in Endodontics: A Narrative Review Afkhami, Farzaneh Forghan, Parisa Gutmann, James L. Kishen, Anil Pharmaceutics Review The efficient elimination of microorganisms and their byproducts from infected root canals is compromised by the limitations in conventional root canal disinfection strategies and antimicrobials. Silver nanoparticles (AgNPs) are advantageous for root canal disinfection, mainly due to their wide-spectrum anti-microbial activity. Compared to other commonly used nanoparticulate antibacterials, AgNPs have acceptable antibacterial properties and relatively low cytotoxicity. Owing to their nano-scale, AgNPs penetrate deeper into the complexities of the root canal systems and dentinal tubules, as well as enhancing the antibacterial properties of endodontic irrigants and sealers. AgNPs gradually increase the dentin hardness in endodontically treated teeth and promote antibacterial properties when used as a carrier for intracanal medication. The unique properties of AgNPs make them an ideal additive for different endodontic biomaterials. However, the possible side effects of AgNPs, such as cytotoxicity and tooth discoloration potential, merits further research. MDPI 2023-02-21 /pmc/articles/PMC10052550/ /pubmed/36986576 http://dx.doi.org/10.3390/pharmaceutics15030715 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Afkhami, Farzaneh Forghan, Parisa Gutmann, James L. Kishen, Anil Silver Nanoparticles and Their Therapeutic Applications in Endodontics: A Narrative Review |
title | Silver Nanoparticles and Their Therapeutic Applications in Endodontics: A Narrative Review |
title_full | Silver Nanoparticles and Their Therapeutic Applications in Endodontics: A Narrative Review |
title_fullStr | Silver Nanoparticles and Their Therapeutic Applications in Endodontics: A Narrative Review |
title_full_unstemmed | Silver Nanoparticles and Their Therapeutic Applications in Endodontics: A Narrative Review |
title_short | Silver Nanoparticles and Their Therapeutic Applications in Endodontics: A Narrative Review |
title_sort | silver nanoparticles and their therapeutic applications in endodontics: a narrative review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10052550/ https://www.ncbi.nlm.nih.gov/pubmed/36986576 http://dx.doi.org/10.3390/pharmaceutics15030715 |
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